In the event that a high COP of a refrigeration cycle is of greater importance compared to other factors, it is possible to significantly increase the COP of a basic cycle through the use of a multistage vapor compression cycle. This is especially true when the pressure ratio between the heat rejection and heat absorption pressures is large 5 or more.

Multistaging involves one or more intermediate pressures between the heat rejection and heat absorption pressures, and a series of compressors operating between successive pressure intervals. One type of multi-compressor vapor compression cycle includes a mixing chamber where saturated vapor from the flash chamber mixes with the vapor leaving the low pressure stage compressor. This vapor-mixing chamber acts as a regenerative intercooler since it cools the superheated vapor leaving the low-pressure stage compressor using lower temperature saturated workin fluid, mixing the two prior to the next stage of compression.

This type of refrigeration cycle is analysed in the following calculation.